Structure-function relationships at the human spinal disc-vertebra interface
نویسندگان
چکیده
منابع مشابه
Structure‐function relationships at the human spinal disc‐vertebra interface
Damage at the intervertebral disc-vertebra interface associates with back pain and disc herniation. However, the structural and biomechanical properties of the disc-vertebra interface remain underexplored. We sought to measure mechanical properties and failure mechanisms, quantify architectural features, and assess structure-function relationships at this vulnerable location. Vertebra-disc-vert...
متن کاملThe Yucatan Minipig Temporomandibular Joint Disc Structure-Function Relationships Support Its Suitability for Human Comparative Studies.
Frequent involvement of the disc in temporomandibular joint (TMJ) disorders warrants attempts to tissue engineer TMJ disc replacements. Physiologically, a great degree of similarity is seen between humans and farm pigs (FPs), but the pig's rapid growth confers a significant challenge for in vivo experiments. Minipigs have a slower growth rate and are smaller than FPs, but minipig TMJ discs have...
متن کاملStructure and Function of the TMJ Disc and Disc Attachments
The TMJ disc is a fibrocartilage tissue, biconcave and elliptical in shape. The disc provides low friction articulation surfaces in the joint. Moreover, its biconcave profile allows a smooth articulation between two incongruent surfaces of the mandibular condyle and the articular eminence. Without the TMJ disc, the incongruent surfaces would have a small area of contact, creating concentrated s...
متن کاملErythropoietin structure-function relationships.
In order to delineate functionally important domains in erythropoietin (Epo), we have prepared and tested a series of amino acid replacements at 51 conserved sites predicted to be on the surface of the molecule. Alanine replacements permitted preservation of a-helical structure. Wild type and mutant Epo cDNAs were transiently expressed at high levels in COS1 and COS7 cells. The biological activ...
متن کاملHigh-field NMR studies of molecular recognition and structure-function relationships in antimicrobial piscidins at the water-lipid bilayer interface.
High magnetic field solid-state NMR was performed on amphipathic cationic antimicrobial peptides from fish to characterize their secondary structure and orientation in hydrated phospholipid bilayers. High-resolution distance and orientational restraints on 13C- and 15N-labeled amidated piscidins 1 and 3 provided site-specific information establishing alpha-helicity and an orientation parallel t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2017
ISSN: 0736-0266
DOI: 10.1002/jor.23627